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Filtered Search Results
Medchemexpress LLC (S,R,S)-Ahpc-C6-Peg3-C4-Cl | 1835705-55-9 | MFCD31560478 | ≥95.0% | 751.42 g/mol | C38H59ClN4O7S | 500 MG
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(S,R,S)-AHPC-C6-PEG3-C4-Cl is a VHL ligand-linker conjugate used as a building block in targeted protein degradation (PROTAC) research. It supplies a halide-terminated PEG linker designed for coupling in degrader synthesis and related medicinal chemistry applications.
- Used as a VHL ligand-linker building block for PROTAC synthesis.
- Molecular formula C38H59ClN4O7S.
- Molecular weight 751.42 g/mol.
- Purity ≥95.0% (manufacturer assay).
- Supplied as a 500 mg solid.
- Storage: pure form -20°C (3 years) or 4°C (2 years); in solvent -80°C (6 months) or -20°C (1 month).
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Medchemexpress LLC Bis-PEG5-acid 5g | 439114-13-3 | 338.35 g·mol⁻1 | C14H26O9 | 5 G
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Bis-PEG5-acid is a polyethylene glycol (PEG)-based bifunctional linker with two terminal carboxylic acid groups, used as a hydrophilic spacer in PROTAC synthesis, bioconjugation, and medicinal chemistry to improve solubility and provide flexibility between binding motifs.
- Provides a flexible PEG5 spacer for conjugation and linker design.
- Two terminal carboxylic acid groups for straightforward coupling chemistry.
- High purity (99.9%) suitable for research applications.
- Available in laboratory pack sizes for small-scale synthesis.
- Enhances aqueous solubility of hydrophobic ligands and intermediates.
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![Medchemexpress LLC 1-Propanamine, 3,3'-[oxybis(2,1-ethanediyloxy)]bis- | 4246-51-9 | >99.9% | 100 G](https://assets.fishersci.com/TFS-Assets/CCG/product-images/default.jpg-250.jpg)
Medchemexpress LLC 1-Propanamine, 3,3'-[oxybis(2,1-ethanediyloxy)]bis- | 4246-51-9 | >99.9% | 100 G
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Bis-NH2-C1-PEG3, also known as PROTAC Linker 24, is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs leverage the intracellular ubiquitin-proteasome system to selectively degrade specific target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Appearance: colorless to light yellow liquid
- Molecular formula: C10H24N2O3
- Molecular weight: 220.31
- Storage: 4°C, protect from light. In solvent: -80°C, 6 months; -20°C, 1 month (protect from light)
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Medchemexpress LLC BM-PEG3 | 86099-06-1 | 98.0% | 100 MG
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BM-PEG3 is a polyethylene glycol (PEG)-based PROTAC linker designed for the synthesis of PROTACs. PROTACs (Proteolysis Targeting Chimeras) are compounds that utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins. They function by connecting two different ligands, one for an E3 ubiquitin ligase and another for the target protein, enabling targeted degradation.
- PEG-based PROTAC linker
- For research use only
- Purity: 98.0%
- Molecular weight: 352.34
- Molecular formula: C16H20N2O7
- Appearance: White to light yellow solid
- Storage as powder: -20°C for 3 years, 4°C for 2 years
- Storage in solvent: -80°C for 6 months, -20°C for 1 month
- Solubility in DMSO: 100 mg/mL (in vitro)
- Solubility in 10% DMSO, 90% corn oil: ≥ 2.5 mg/mL (in vivo)
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Medchemexpress LLC (S,R,S)-AHPC-C6-PEG3-C4-Cl | 1835705-55-9 | MFCD31560478 | >95.0% | 751.42 g/mol | C38H59ClN4O7S | 2 G
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(S,R,S)-AHPC-C6-PEG3-C4-Cl is a VHL E3 ligase ligand-linker conjugate used as a building block for PROTAC design and targeted protein degradation research. It combines a stereodefined AHPC VHL ligand with a mixed C6-PEG3-C4 linker and has been used in cell-based assays to induce degradation of HaloTag fusion proteins.
- Used as a VHL E3 ligase ligand building block for PROTAC synthesis.
- Soluble in DMSO at 100 mg/mL (may require ultrasonication).
- Suitable for in vivo formulations at ≥2.5 mg/mL in recommended cosolvent systems.
- Stable in pure form when stored at -20°C for extended periods.
- Molecular weight 751.42 g/mol and molecular formula C38H59ClN4O7S.
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Medchemexpress LLC m-PEG5-Br | 854601-80-2 | 98.0% | C11H23BrO5 | 25 G
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m-PEG5-Br is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs are designed to selectively degrade target proteins by utilizing the intracellular ubiquitin-proteasome system. They achieve this by connecting two ligands: one for an E3 ubiquitin ligase and another for the target protein.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the ubiquitin-proteasome system
- Selectively degrades target proteins
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eMolecules 867062-95-1 | Fmoc-NH-PEG3-CH2CH2COOH | ChemScene | MFCD06656471 | 443.496 | C24H29NO7 | 96.000 | OC(=O)CCOCCOCCOCCNC(=O)OCC1c2ccccc2-c2ccccc12 | 100mg | 844793195
Fmoc-NH-PEG3-CH2CH2COOH | ChemScene | 867062-95-1 | MFCD06656471 | 443.496 | C24H29NO7 | 96.000 | OC(=O)CCOCCOCCOCCNC(=O)OCC1c2ccccc2-c2ccccc12 | 100mg | 844793195
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Medchemexpress LLC THP-PEG5-OH | 100MG
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THP-PEG5-OH | 100MG
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Medchemexpress LLC Bis-PEG3-acid | 96517-92-9 | 97.0% | 250 MG
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Bis-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- Intended for research use only
- Not sold to patients
- Viscous liquid appearance
- Colorless to light yellow color
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Medchemexpress LLC Azido-PEG3-C6-Cl | 1625717-44-3 | 95.3% | 293.79 | 50 MG
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Azido-PEG3-C6-Cl | 1625717-44-3 | 95.3% | 293.79 | 50 MG
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Medchemexpress LLC (S,R,S)-AHPC-PEG3-NH2 hydrochloride | 2097971-11-2 | MFCD31656714 | 99.0% | 656.23 g/mol | C30H46ClN5O7S | 50 MG
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(S,R,S)-AHPC-PEG3-NH2 hydrochloride is a VHL E3 ligase ligand-linker conjugate featuring an AHPC-derived VHL-binding warhead connected to a three-unit polyethylene glycol spacer terminating in a primary amine; it is supplied as the hydrochloride salt and is used as a building block in PROTAC synthesis and E3 ligase ligand studies.
- Contains AHPC-derived VHL-binding warhead with defined stereochemistry.
- Three-unit PEG spacer terminating in a primary amine for conjugation.
- Provided as the hydrochloride salt for improved stability and handling.
- Intended for use in PROTAC design and E3 ligase ligand research.
- Requires cold, inert storage and protection from light.
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(OC)c1ccccc1 | 10g | 525102076](https://assets.fishersci.com/TFS-Assets/CCG/product-images/NC2039302.JPG-250.jpg)
eMolecules 3027-21-2 | Dimethoxy(methyl)(phenyl)silane | Ambeed | MFCD00008343 | 182.294 | C9H14O2Si | 98 | CO[Si](C)(OC)c1ccccc1 | 10g | 525102076
Ambeed | (S)-2-((2R3R)-3-((S)-1-((3R4S5S)-4-((S)-N3-Dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamido)-3-methoxy-5-methylheptanoyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanamido)-3-phenylpropanoic acid | 2mg | 491171472 | A309085 | 745017-94-1 | MFCD25976742 | 731.976 | C39H65N5O8
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eMolecules Building Block Tool<|a>
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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eMolecules 887375-37-3 | 4-(5-Fluoro-2,3-dihydrobenzofuran-7-yl)-4-methyl-2-(trifluoromethyl)pentane-1,2-diol | Synthonix - Stock322.300 | C15H18F4O3 | 95.000 | CC(C)(CC(O)(CO)C(F)(F)F)c1cc(F)cc2CCOc12 | 1g | 495878459
4-(5-Fluoro-2,3-dihydrobenzofuran-7-yl)-4-methyl-2-(trifluoromethyl)pentane-1,2-diol | Synthonix - Stock | 887375-37-3322.300 | C15H18F4O3 | 95.000 | CC(C)(CC(O)(CO)C(F)(F)F)c1cc(F)cc2CCOc12 | 1g | 495878459
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Accela Chembio Inc 2 | 2'-bis(trifluoromethyl)benzidine | 25g | 341-58-2 | MFCD00190155 | 97+% | Shelf Life: 1260 Days | Light Sensitive
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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2 | 2'-bis(trifluoromethyl)benzidine | 25g | 341-58-2 | MFCD00190155 | 97+% | Shelf Life: 1260 Days | Light Sensitive
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![eMolecules 164526-16-3 | (7-Amino-2,3-dihydrobenzo[1,4]dioxin-6-yl) (2-chlorophenyl)methanone | Oakwood Chemical | MFCD00561832 | 289.720 | C15H12ClNO3 | 95.000 | Nc1cc2OCCOc2cc1C(=O)c1ccccc1Cl | 100mg | 537683527](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502149491.JPG-250.jpg)
eMolecules 164526-16-3 | (7-Amino-2,3-dihydrobenzo[1,4]dioxin-6-yl) (2-chlorophenyl)methanone | Oakwood Chemical | MFCD00561832 | 289.720 | C15H12ClNO3 | 95.000 | Nc1cc2OCCOc2cc1C(=O)c1ccccc1Cl | 100mg | 537683527
(7-Amino-2,3-dihydrobenzo[1,4]dioxin-6-yl) (2-chlorophenyl)methanone | Oakwood Chemical | 164526-16-3 | MFCD00561832 | 289.720 | C15H12ClNO3 | 95.000 | Nc1cc2OCCOc2cc1C(=O)c1ccccc1Cl | 100mg | 537683527
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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