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Filtered Search Results
Apexbio Technology LLC OSI-420 free base 183321-86-0 5mg
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OSI-420 free base (CAS 183321-86-0) is an active metabolite of erlotinib (OSI-774) exhibiting inhibitory activity against epidermal growth factor receptor (EGFR) tyrosine kinase Mechanistically OSI-420 inhibits EGFR by binding competitively to the ATP-binding site within the intracellular kinase domain thus preventing receptor autophosphorylation and subsequent signaling Additionally through EGFR inhibition it can trigger apoptosis via mitochondrial disruption including loss of mitochondrial membrane potential and cytochrome c release OSI-420 is utilized in biomedical research for studying EGFR-related signaling pathways and apoptosis mechanisms
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Medchemexpress LLC BOCNH-PEG5-CH2CH2BR 50MG
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5000205718 BOCNH-PEG5-CH2CH2BR 50MG
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Medchemexpress LLC TFP-PEG3-TFP 50mg
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TFP-PEG3-TFP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]
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CAMPBELL SCIENCE BSTFA + 1% TMCS | 25561-30-2 | MFCD00008269 | 100 g
BSTFA + 1% TMCS | Purity: 98% | Mol Wt: 257.40 | 25561-30-2 | MFCD00008269 | 100 g
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![Medchemexpress LLC Hydroxylamine, O-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethyl]- | 1306615-51-9 | 95.0% | 234.25 g/mol | C8H18N4O4 | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000204191.png-250.jpg)
Medchemexpress LLC Hydroxylamine, O-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethyl]- | 1306615-51-9 | 95.0% | 234.25 g/mol | C8H18N4O4 | 50 MG
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Aminooxy-PEG3-azide is a bifunctional PEG3 linker reagent containing an aminooxy group and an azide group, used for bioconjugation in ADC and PROTAC synthesis and for click chemistry conjugations.
- Contains an aminooxy group for oxime ligation.
- Contains an azide group for CuAAC and SPAAC click chemistry.
- Three-unit PEG spacer provides solubility and flexibility.
- High purity suitable for research applications.
- Stable when stored at -20°C in pure form.
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Medchemexpress LLC MEDCHEMEXPRESS LLC
5000429654 HYDROXYL MAGNETIC BE 25ML
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eMolecules CYCLOPENT-1-EN-1-YLBORONI 5G
5000160221 CYCLOPENT-1-EN-1-YLBORONI 5G
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Medchemexpress LLC 2',3'-O-isopropylidene-6-mercaptopurine riboside | 5856-48-4 | MFCD00051198 | 96.6% | 324.36 | C13H16N4O4S | 50 MG
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2',3'-O-isopropylidene-6-mercaptopurine riboside is an isopropylidene-protected nucleoside derivative used as a research reagent with notable metal complexing activity. It is supplied as a solid for laboratory use and should be handled and stored under appropriate conditions to preserve stability.
- CAS number 5856-48-4.
- Molecular formula C13H16N4O4S.
- Molecular weight 324.36.
- Purity approximately 96.6%.
- Packaged quantity 50 MG.
- Appearance solid, white to off-white.
- Storage: powder at -20°C up to 3 years; in solvent -80°C for 6 months or -20°C for 1 month.
- Application for studying metal complexing mechanisms in research.
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eMolecules 3- TERT-BUTYLDIMETHYLSILYL 1G
5000188419 3- TERT-BUTYLDIMETHYLSILYL 1G
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Medchemexpress LLC Bis-PEG5-acid 25g | 439114-13-3 | 338.35 | C14H26O9 | 25 G
Bis-PEG5-acid (4,7,10,13,16-pentaoxanonadecanedioic acid) is a polyethylene glycol (PEG)-based dicarboxylic acid linker used as a building block in PROTAC and medicinal chemistry. The hydrophilic PEG spacer provides aqueous solubility and flexibility for conjugation, and the two terminal carboxylic acid groups enable standard coupling reactions. Purity and lot-specific certificate of analysis are provided with each shipment.
- PEG-based dicarboxylic acid linker for PROTAC synthesis
- Two terminal carboxylic acid groups for amide or ester coupling
- Hydrophilic spacer increases solubility in aqueous media
- White to yellow solid, suitable for handling and storage
- Supplied in gram-scale quantities with batch certificate of analysis
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Medchemexpress LLC Dbco-PEG3-VC-Exatecan | 2754384-70-6 | 96.7% | 1331.44 g/mol | C71H79FN10O15 | 10 MG
DBCO-PEG3-VC-Exatecan is a drug-linker conjugate used in antibody-drug conjugate (ADC) research that couples a DBCO-functionalized PEG3 valine-citrulline cleavable linker to the topoisomerase I inhibitor exatecan.
- Provides a cleavable valine-citrulline (VC) linker for intracellular release.
- Includes a DBCO handle for strain-promoted azide-alkyne cycloaddition (click chemistry).
- Incorporates a PEG3 spacer to improve solubility and linker flexibility.
- Delivers exatecan, a DNA topoisomerase I inhibitor payload.
- High purity (~96.7%) and large molecular weight (~1331.44 g/mol).
- Soluble in DMSO at 50 mg/mL with ultrasonic assistance.
- Stored sealed at -20 °C; in solution, stable at -80 °C for 6 months and -20 °C for 1 month.
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eMolecules 3-(t-Butyldimethylsilyloxy)-4-chloro-2-fluorophenylboronic acid | 1256354-94-5 | MFCD17015761 | 1g
Combi-Blocks | 3-(t-Butyldimethylsilyloxy)-4-chloro-2-fluorophenylboronic acid | 1g | 117524740 | BB-6525 | 95.000 | 1256354-94-5 | MFCD17015761 | 304.620 | C12H19BClFO3Si
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![Medchemexpress LLC 5,8,11-trioxa-2-azatridecanoic acid, 13-hydroxy-, bicyclo[6.1.0]non-4-yn-9-ylmethyl ester | 2126749-77-5 | 99.6% | 369.45 | C19H31NO6 | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000203923.png-250.jpg)
Medchemexpress LLC 5,8,11-trioxa-2-azatridecanoic acid, 13-hydroxy-, bicyclo[6.1.0]non-4-yn-9-ylmethyl ester | 2126749-77-5 | 99.6% | 369.45 | C19H31NO6 | 5 MG
BCN-PEG3-OH is a BCN-functionalized PEG linker with a terminal hydroxyl group used for bioorthogonal click chemistry to attach payloads in bioconjugation and antibody-drug conjugate synthesis.
- enables strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules.
- contains a three-unit polyethylene glycol spacer and a BCN reactive group.
- high purity (99.6% by LCMS) and molecular weight 369.45 g/mol.
- chemical formula C19H31NO6, cas 2126749-77-5.
- store under nitrogen at -20°C; in solvent, -80°C for up to 6 months, -20°C for up to 1 month.
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eMolecules Combi-Blocks tert-Butyldimethylsilyl chloride 1kg 117541944 OT-0329 98 000 18162-48-6 MFCD00000501 150 720 C6H15ClSi
Combi-Blocks tert-Butyldimethylsilyl chloride 1kg 117541944 OT-0329 98 000 18162-48-6 MFCD00000501 150 720 C6H15ClSi
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC Chloro-PEG5-chloride 1g
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Chloro-PEG5-chloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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